umbelliprenin from ferula szowitsiana activates both intrinsic and extrinsic pathways of apoptosis in jurkat t-cll cell line

Authors

omid gholami pharmacology department, faculty of medicine, shahid beheshti university of medical sciences, tehran, ir iran.

mahmood jeddi-tehrani monoclonal antibody research center, avicenna research institute, acecr, tehran, ir iran.

mehrdad iranshahi biotechnology research center and school of pharmacy, mashhad university of medical sciences, mashhad, ir iran.

amir hassan zarnani nanobiotechnology research center, avicenna research institute, acecr, tehran, ir iran.

abstract

umbelliprenin is a prenylated compound, which belongs to the class of sesquiterpene coumarins. it is extracted from dried roots of ferula szwitsiana collected from the mountains of golestan forest (golestan province, north of iran). induction of apoptosis in jurkat t-cll cells has been previously shown. in this study, effect of umbelliprenin on proapoptotic caspases (caspase-8 and -9) and antiapoptotic bcl-2 family protein was studied. jurkat cells were incubated with umbelliprenin. cells were then lysed and activation of proteins was studied by western blot analysis. in this study, we showed that umbelliprenin activates intrinsic and extrinsic pathways of apoptosis by the activation of caspase-8 and -9 respectively. inhibition of bcl-2 was also shown. in conclusion, umbelliprenin induced apoptosis in jurkat cells through caspase-dependent apoptosis pathway.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Umbelliprenin from Ferula szowitsiana Activates both Intrinsic and Extrinsic Pathways of Apoptosis in Jurkat T-CLL Cell Line

Umbelliprenin is a prenylated compound, which belongs to the class of sesquiterpene coumarins. It is extracted from dried roots of Ferula szwitsiana collected from the mountains of Golestan forest (Golestan Province, north of Iran). Induction of apoptosis in Jurkat T-CLL cells has been previously shown. In this study, effect of umbelliprenin on proapoptotic caspases (caspase-8 and -9) and antia...

full text

Umbelliprenin from Ferula szowitsiana Activates both Intrinsic and Extrinsic Pathways of Apoptosis in Jurkat T-CLL Cell Line

Umbelliprenin is a prenylated compound, which belongs to the class of sesquiterpene coumarins. It is extracted from dried roots of Ferula szwitsiana collected from the mountains of Golestan forest (Golestan Province, north of Iran). Induction of apoptosis in Jurkat T-CLL cells has been previously shown. In this study, effect of umbelliprenin on proapoptotic caspases (caspase-8 and -9) and antia...

full text

Umbelliprenin from Ferula szowitsiana Activates both Intrinsic and Extrinsic Pathways of Apoptosis in Jurkat T-CLL cell line

Umbelliprenin is a prenylated compound, which belongs to the class of sesquiterpene coumarins. It is extracted from dried roots of Ferula szwitsiana collected from the mountains of Golestan forest (Golestan Province, north of Iran). Induction of apoptosis in Jurkat T-CLL cells has been previously shown. In this study, effect of umbelliprenin on proapoptotic caspases (caspase-8 and -9) and antia...

full text

Umbelliprenin Induces Apoptosis in CLL Cell Lines

    Chronic lymphocytic leukemia (CLL) remains an incurable disease that requires innovative new approaches to improve therapeutic outcome. Many Ferula species, including F. asa-foetida, synthesize terpenyloxy coumarins. One of these coumarins is umbelliprenin, which has been implicated with induction of apoptosis in some cancer cell lines.     In this study induction of apoptosis by umbellipre...

full text

Umbelliprenin Induces Apoptosis in CLL Cell Lines

    Chronic lymphocytic leukemia (CLL) remains an incurable disease that requires innovative new approaches to improve therapeutic outcome. Many Ferula species, including F. asa-foetida, synthesize terpenyloxy coumarins. One of these coumarins is umbelliprenin, which has been implicated with induction of apoptosis in some cancer cell lines.     In this study induction of apoptosis by umbellipre...

full text

Umbelliprenin Induces Apoptosis in CLL Cell Lines

Chronic lymphocytic leukemia (CLL) remains an incurable disease that requires innovative new approaches to improve therapeutic outcome. Many Ferula species, including F. asa-foetida, synthesize terpenyloxy coumarins. One of these coumarins is umbelliprenin, which has been implicated with induction of apoptosis in some cancer cell lines. In this study induction of apoptosis by umbelliprenin on J...

full text

My Resources

Save resource for easier access later


Journal title:
iranian journal of pharmaceutical research

جلد ۱۲، شماره ۳، صفحات ۳۷۱-۳۷۶

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023